Enzyme synthesis in the regulation of hepatic ‘malic’ enzyme activity
نویسندگان
چکیده
منابع مشابه
Regulation of hepatic malic enzyme mRNAs during development.
Previous studies in vivo have demonstrated that in neonatal and adult rats hepatic malic enzyme expression is controlled at the pretranslational level by dietary and hormonal factors [ 1, 21. However, in order to demonstrate that particular effectors have a direct effect on gene expression in liver cells, techniques in vitro, such as the use of primary cultures of non-proliferating rat hepatocy...
متن کاملRegulation of mitochondrial malic enzyme synthesis in mouse brain.
In a previous study [Bernstine, E.G. (1979) J. Biol. Chem. 254, 83-87] it was shown that inbred strains of mice fall into two classes based on the specific activity of mitochondrial malic enzyme [L-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating), EC 1.1.1.40] in brain. In this report we demonstrate differences between high- and low-activity strains in the development of enzyme activi...
متن کاملcomparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولTranscriptional regulation of the Schizosaccharomyces pombe malic enzyme gene, mae2.
The NAD-dependent malic enzyme from Schizosaccharomyces pombe catalyzes the oxidative decarboxylation of L-malate to pyruvate and CO2. Transcription of the S. pombe malic enzyme gene, mae2, was studied to elucidate the regulatory mechanisms involved in the expression of the gene. No evidence for substrate-induced expression of mae2 was observed in the presence of 0.2% L-malate. However, transcr...
متن کاملRegulation of malic enzyme synthesis by insulin triiodothyronine, and glucagon in liver cells in culture.
Cells isolated from the livers of 17- to 19-day-old chick embryos were maintained in a chemically defined culture medium. During 3 days in culture the activity of malic enzyme, a measure of its concentration, was stimulated 2-, 23-, or 77-fold by insulin, triiodothyronine, or insulin plus triiodothyronine, respectively. Glucagon blocked the stimulation caused by insulin plus triiodothyronine. C...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1974
ISSN: 0264-6021
DOI: 10.1042/bj1440149